THE SMART TRICK OF LDN-27219 CLINICAL TRIALS THAT NO ONE IS DISCUSSING

1 particularly exciting compound is LDN-27219. Although most tTG inhibitors are made to bind to the protein crosslinking Energetic web site, LDN-27219 as an alternative binds towards the nucleotide binding pocket on the enzyme although it's in its shut-state conformation, and stabilizes that conformation to forestall crosslinking activity.78 Schnei